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10/7/2023 0 Comments Precise diagnostics llcWe are analysing this in our upcoming Phase 2 study to determine the potential as a non-invasive biomarker. Our precision medicine approach will leverage the detection of raised MPO levels in blood and sputum. MPO is an enzyme that leads to inflammation-induced tissue damage and disease exacerbations. This precision medicine approach will help us identify potential novel targets for life-changing medicines.” Ken Grime, Executive Director and Head of Bioscience COPD, AstraZeneca.īy targeting disease drivers of COPD, such as oxidative stress, cell senescence, chronic inflammation and fibrosis, we aim to develop precision medicines focused on disease modification so as to slow and stop disease progression.Ī newer area of interest is the key upstream mediator of oxidative stress, myeloperoxidase (MPO). 2 To address this, we are dissecting the 500+ abnormally expressed genes and defining their role in disease. “In chronic obstructive pulmonary disease (COPD) we have seen little innovation in decades despite it being the third leading cause of death world-wide. In the future, our ambition is to provide tailored treatments based on individual disease, or patient, categories determined by molecular disease drivers.Ĭhronic obstructive pulmonary disorder (COPD) We are now looking to identify urinary biomarkers which could be used to identify patients’ molecular disease classes non-invasively, allowing us greater precision when aligning the right patients to the right trials. For the first time, our research has shown that these disease categories based on molecular data are different from previous clinical classifications for CKD. Using unique datasets, the team has applied machine learning and artificial intelligence algorithms to classify patients into subclasses. Our aim is to close this gap, by uncovering the underlying genetic and molecular drivers of disease to identify the right treatment for the right patient.” Pernille Laerkegaard Hansen, Executive Director and Head of Bioscience Renal, AstraZeneca. The current symptom-based approach ignores the different underlying mechanisms. “Chronic Kidney Disease (CKD) encompasses various primary disorders and stages of progression, and the patient population is highly heterogenous. To improve patient outcomes, we must move beyond the current standard of care in which many patients are treated the same (a ‘one-size-fits-all’ approach) and sequentially across the disease pathway, and towards the possibility of targeting treatments to specific and earlier disease states. It is for these reasons that chronic obstructive pulmonary disease and chronic kidney disease have seen little innovation in decades and there are no approved treatments for the metabolic disorder non-alcoholic steatohepatitis. Currently, diagnosis relies on clinical symptoms and standard biomarkers – patient characteristics such as a gene, molecule, or other (e.g., blood pressure) – however, tests are often limited, imprecise and late in disease progression. They are heterogenous from how they present over time with an array of different symptoms and co-morbidities, to the way they are diagnosed over the course of disease. The challenge we face is that chronic diseases are biologically complex and driven by multiple mechanisms. Partnerships, alliances and recognitionĬhronic diseases affect billions of people worldwide and numbers are expected to rise considerably in future years. 10/6/2023 0 Comments Tot catIn 2010 the club was taken over by Piroj Suwannachavee and renamed the team as TOT-CAT FC. The accomplishment in the early days of the club is honorably credited to the first well-known coach Pongphan Wongsuwan. Notable other achievements have been winning the Thai FA Cup in 1993 and the now-defunct Pro League in 2006 with their reserve team. They have been relegated on two occasions, bouncing back to the top flight at the first time of asking and claiming the Division One championship in the 2003/04 season. īesides being relegated to the Thailand Division 1 League in 2003, they have more or less been a middle-ranking team, yet to break into the top four since 1996/97. This has so far proved to be TOT's best campaign. TOT SC is a founding member of the Thai Premier League in 1996/97 season and came second in the regular-season championship but was defeated by Bangkok Bank F.C. TOT's football team is a member of Football Association of Thailand (FAT) and a co-founder of the Thai Premier League. TOT originally stands for the Telephone Organization of Thailand, the former name of the company at the time before their privatization. TOT Sport Club ( Thai: ทีโอที สปอร์ต คลับ) is a Thai defunct football club based in Lak Si district in northern Bangkok which represents the national telecommunications company, TOT Public Company Limited. Whole thing seems daft - why on earth dont TOT just completly swallow up TT&T?, would be a massive cost saving. in fact if you dont pay your TT&T bill by the due date - they tell you to go to the TOT office to pay. Not sure in Phuket (cos I has CS Loxinfo on my TT&T line, so was only paying my TT&T phone bill at TOT) but in CM you can. Not a big deal but its made more complex as bills were set up to go to my landlords office and hes out of the country, so I have to guess when its due and go and pay without any numbers or invoices. Yeah but I cant pay my maxnet bill at TOT (can I ?).īefore I had one bill for phone and internet now I have 2. TT&T is 80%+ owned by TOT so you can pay your TT&T bill at the TOT office - I did in Phuket (Central) and I do in CM, as I have both TOT andTT&T lines. When I had TOT it was much easier, i could walk in the office, with nothing more than my home phone number, tell them over the counter and they would pay off all outstanding balance. TOT or CAT? And if it is CAT, why am I still being billed for a service I have already paid TOT for? Anyone? What a shower. Who the hel_l is responsible for billing for TOT ADSL. In the meantime, I am still receiving bills, backdated, from CAT for a service I had called to discontinue, on several occasions, but told 'YOU MUST PAY' again. After explaining my problem and his calling another department, it was found that I must indeed call upon all my supernatural powers and guess when a bill from TOT might be due, and go back to the office and pay it. I duly tiptoed up to TOT, where old bat had vanished and found lone speccy clerk hopelessly attempting to run entire department on his own, juggling ringing 'phones and disgruntled customers. Thai businessmen should surely hold TOT up as a shining beacon of how to run their businesses here. I then received a rather nasty telephone call from an old bat at TOT to tell me "You Not Pay!" Before slamming the 'phone down. I called CAT on the local telephone number helpfully given on their bill to tell them I had indeed now at last had ADSL and had binned their modem some months previously. I didn't receive a bill from them for three months, but I did continue to receive bills from CAT for the marvelous HUAWEI dial up modem I had happily suffered for the previous year. A few months ago the wonderful people at TOT finally installed a telephone line and I subscribed to their fantastic hyper speed of light ADSL. 10/6/2023 0 Comments Spy cam wifi ipThus making the camera, a must buy the product. The miniature camera has a great memory space which can be improved by using an SD card of about 32 GB. One can transfer the videos and watch anywhere with the help of USB cable that not only charges but also transfers data. Having a wide 130 degrees View Angle, IR Night Vision, and Wi-Fi IP Network Function not only provide a wide coverage area but it also makes the picture visible and provide suitable lighting in the case of night. When the camera detects the motion, it automatically starts recording and sends it to your email id. The other feature present is motion detection, one- key booting, night vision, etc. The hidden camera can record video as well as audio. 3) Open 'HIDVCAM', Refresh the device list on the APP, you can view connected camera. 2) Go to the WIFI setting page, then connect the Wi-Fi named IPC-XXXXX. The working capacity of these products is too high due to the Li battery. 1) Turn on camera: Press ON/OFF to turn on the camera, in 10 seconds, and the blue light bright, the red light flashes slowly. Recording can happen even while charging. With night comes low visibility this problem is taken care of by the night vision feature giving appropriate light for the actions to be captured. The record here occurs on the basis of the motion happening around the camera. Continuously record on the SD card can occur here although the internal storage is great, it can also be increased by inserting an SD card. If any motion detected, it sends a buzz on the mobile phone making a person alert if some random person gets inside the house, etc. Anyone can see what is happening at an area anytime and anywhere. The camera needs to connect to a 2. Nobody will suspect this standard non-functional smoke detector, which secretly hides a built-in IP camera. This Wi-Fi, IP camera transmits secure, interference free, high resolution HD video signal directly to your wireless router for remote viewing and recording. Remote Live view on your iPhone, iPad, an Android phone from any place makes work very easy. : Spy Camera Smoke Detector Hidden Camera - WiFi 180 Days Standby 1080P HD Night Vision PIR Motion Detection Video Recorder Ceiling Nanny Cam : Electronics. This is a wireless camera comes with high resolutions. If the spy camera detects any movement, then immediately sends an alarm to your phone at any time. This will helps you to monitor the place and at any time. The ideal solution to monitor your house nanny is to fix the wireless IP Camera Hidden Nanny Cam. Wireless SPY Camera Nanny Cam Anti Theft Best Buy Australia 10/6/2023 0 Comments Forza horizon 3 patch notesReduced Transmission whine on stock car audio '70 Mercury Cyclone Spoiler - Stock brakes can't be paintedįixed DeLorean logo on Car Collection screen '18 BMW M5 - Corrected colour in front left brake calliper '98 Toyota Supra RZ - Corrected window trim issue and various other fixes to upgrade partsĪdded Freeroam Convertible functionality to the Willys Jeep and Porsche 918 Spyder Improved messaging around out of date drivers Stopped mouse being able to move the camera during Pre-Race cinematicįixed an issue where low video memory warning could be displayed incorrectly on AMD Renoirįixed an issue where running at 3440x1440 resolution would cause graphical artefacts on the screen edge Made car restrictions for Horizon Tour clearerįixed issue where beating a record in Rivals and Series Rivals wouldn't provide a new rival in the post-race screenįixed issue where players could see incorrect points total in Playground Games events when a player leftįixed issue where no traffic was present for online street racesįixed issue with destination pin when playing expeditions in co-opįixed issue with AI cars disappearing when playing expeditions in co-opįixed an issue where button prompts were not appearing for users with a Logitech G920įixed an issue where players could tune their car to a higher class vehicle before starting a raceįixed an issue where times from Blueprint events could be erroneously posted to the leaderboard for the race at that locationįixed an issue where players were able to post to Rivals and PR Stunt leaderboards when using modified game speed settingsįixed issue where Pause Menu could show two tabs at once when changing focus away from the game and unpausing with a controllerįixed issue where mouse input was being ignored in the Horizon Story Post Race Stars screen Horizon Arcade - Reduced the completion requirements as part of Festival Playlist Horizon Arcade - Fixed an issue where some ramps might not appear during Horizon Arcade bullseye events Horizon Arcade - Added unique icons for each Horizon Arcade game type on the map Horizon Arcade - Fixed issue where Horizon Arcade Mini Missions HUD wouldn't show players when next mission is starting Horizon Arcade - Fixed issue where finding a Barn Find during a Horizon Arcade event could leave players in a bad game state Horizon Arcade - Adjusted completion requirements for some Horizon Arcade events Horizon Arcade - Increased the time at which a Horizon Arcade event radius will appear on the map ahead of it starting to 10 minutes Horizon Arcade - Prioritise grouping players in larger groups when event starts Horizon Arcade - Fixed an issue where convoy members were seeing different score totals Horizon Arcade - Score target now scales based on number of participants Horizon Open - Fixed issue with scoring HUD in Open DriftingĮliminator - Randomised position of Eliminator car dropsįixed an issue where searching for a convoy via 'Find a Convoy' could result in an infinite loadĬonvoy leaders accepting a Forza LINK invite now accepts for the whole convoyĬonvoy icon on Player Label in the map has been updated to be more readable Horizon Open - Removed S2 Cross Country races from rotation Horizon Open - Street Race routes will now be at night Horizon Open - Removed The Goliath from pool to prevent long wait for race completion Horizon Open - Reduced the amount of races in Open Racing events before a car change, from 5 to 3 Improvements for an issue where convoy members and other players can disappear Moreover, the developers have fixed the game's bug with 1440p display resolution on PC that could cause some visual problems.īelow, you can check out the full details for the latest Forza Horizon 5 update.įorza Horizon 5 Update - Patch Notes (December 3)įixed crash that could occur when loading Chapter 6 in the Born Fast Horizon Storyįixed crash that could occur when replaying the Canyon Expeditionįixed a soft lock which could occur during the Baja Expedition PC players with AMD graphics cards will also get rid of the low memory warning. Also, the multiplayer section of the game is expected to provide a much smoother experience with no disconnections. With this new update, the players will experience fewer game crashes. CHECK THIS OUT: How to Get Forzathon Points in Forza Horizon 5.Just a few hours earlier, Playground Games delivered the second update for Forza Horizon 5 which improves the game's stability and fixes tons of bugs related to cars, the game's world, and other features. Tons of fixes and improvements coming to Forza Horizon 5 with today's update on both PC and console versions. 10/6/2023 0 Comments Zeito shion and kaitoNotable media Additional info Relationships he Doesn't Care For Zatsune Miku, he is more like the Antagnistic Ego of Kaito. He is Just a Simple Black Recolored of Kaito.Unlike Zeito who is Calm and has the Dere Part. he Repared to Be Evil.Despotic,Ruling and Rather Same Similarity to Zatsune's Nature. He has a whole lot Different Personality. a Simple Recolor with a Antagonistic Look. He has Black Hair, Brown Pants,Dark Red Scarf and Ruby Eyes. not to Be Confused with Shion Zeito with the Similarities.
I sold my crypto on RH which showed up instantly within my withdrawable funds and did not have to wait for that to settle. The awesome thing about Coinbase is that I've had an account and was able to add all of the verification steps to make sure my instant deposit limit was 25k. You just have to wait for the manual micro deposits to show up in your Robinhood Cash Management which took me about 2.5 days to show up and verify. When you are in Coinbase it is pretty glitchy when you try to use the Plaid instant connect feature to add RH as an ACH, however just "x" out of the window and manually enter in your ACH and Routing Number for your RH Cash Management account. Saw this thread a couple days ago since I've been pretty worried about the whole RH crypto situation and wanted to comment to let the people know that this does in fact work and I just was able to move over my funds today which was a huge relief. Some alt coins blow away BTC in their returns (but yes, they're much riskier). Also, another possible opportunity cost is that you cannot use ETH if you hold it to purchase alt coins on places like UniSwap. Another is that some kind of bug with the exchange's software causes the crypto to disappear.Īn opportunity cost to consider with keeping crypto at Robinhood is the lack of ability to earn interest on your crypto that some places like Celsius and BlockFi offer (they both currently advertise > 6% APY and at Celsius it's compounded weekly). Other risks are common to just about any crypto exchange, like the exchange gets hacked and your crypto is stolen. The biggest risk, to me, right now is that Robinhood ends up going bankrupt and I lose all the crypto I hold with Robinhood. That means to ask yourself what risks do you carry by continuing to keep your crypto at Robinhood? I can think of a few things. The thing to think about is "counter party risk". The CSS used by this subreddit is the Erdune Theme modified by /u/Annihilia and /u/konkedas. You MUST verify the integrity of this software before running it.Latest stable version: 25.0 (May 2023).You can also use Bitcoin Core as a very secure Bitcoin wallet. If you have a fairly powerful computer that is almost always online, you can help the network by running Bitcoin Core. Almost all Bitcoin wallets rely on Bitcoin Core in one way or another. #bitcoin Other Bitcoin sitesīitcoin Forum Bitcoin Stack Exchange Bitcoin Magazine Download Bitcoin Coreīitcoin Core is the backbone of the Bitcoin network. Do not post your Bitcoin address unless someone explicitly asks you to.Aside from new merchant announcements, those interested in advertising to our audience should consider Reddit's self-serve advertising system. New merchants are welcome to announce their services for Bitcoin, but after those have been announced they are no longer news and should not be re-posted. Please avoid repetition - /r/bitcoin is a subreddit devoted to new information and discussion about Bitcoin and its ecosystem.r/Bitcoin is primarily for news and discussion. For example, submissions like "Buying 100 BTC" or "Selling my computer for bitcoins" do not belong here. Trades should usually not be advertised here.Promotion of client software which attempts to alter the Bitcoin protocol without overwhelming consensus is not permitted.Submissions that are mostly about some other cryptocurrency belong elsewhere.This subreddit is not about general financial news. News articles that do not contain the word "Bitcoin" are usually off-topic.Only requests for donations to large, recognized charities are allowed, and only if there is good reason to believe that the person accepting bitcoins on behalf of the charity is trustworthy. Begging/asking for bitcoins is absolutely not allowed, no matter how badly you need the bitcoins.Do not use URL shortening services: always submit the real link.If you are new to Bitcoin, check out We Use Coins and. As such, it is more resistant to wild inflation and corrupt banks. Unlike traditional currencies such as dollars, bitcoins are issued and managed without any central authority whatsoever: there is no government, company, or bank in charge of Bitcoin. Bitcoin is the currency of the Internet: a distributed, worldwide, decentralized digital money. 10/6/2023 0 Comments Vanilla balance checkOur product offerings include millions of PowerPoint templates, diagrams, animated 3D characters and more. is brought to you by CrystalGraphics, the award-winning developer and market-leading publisher of rich-media enhancement products for presentations. Then you can share it with your target audience as well as ’s millions of monthly visitors. 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Whole you realize the individual you love, truly Not just young people love to get gifts, even Title: Check My Vanilla Visa Balance | Onevanilla Balance Check Online 10/6/2023 0 Comments Aquapark io appI had gotten all the water parks so I wasn’t excited for the next course 2. This game is super fun and I can’t stop playing it until. Overall, this game is an okay game and NEEDS changes. I do not like how you have to watch ads to unlock certain features or pay money for no ads. If there were real people playing or you could invite your friends to a friends only round it would be much more fun and competitive especially with yours friends. When games are easy, they are not very fun and you get bored easily. The problem with these type of games is that they make it very easy for you and then praise you and make you think you are skilled or something and then you give the game a good review. They should add boosters, for example every time when you win three times in a row you should get like, one super speed booster or something like that. One feature that I like about this game is how you can go off the slide and try getting into the swimming pool. If you are first place, the bots can just catch up and pass you in a couple of seconds. It is unfair how you start sixteenth place and the other “players” start before you. Second, there aren’t real people playing. Some ads when you click the X it takes you to the App Store and you have to go back to the game. Some are only a few seconds which aren’t too bad. Some ads are very long like thirty seconds. This is at first was very entertaining, but right after the first level that I played I got an ad. They probably use these ads to gain money (since this game is pretty much free of charges). If you don’t know how to get one just search on YT or something. That’s all I think I’ve gotta say, overall good game if it weren’t for the repetitive stages, bots (non-real-players), and the instant catch-ups (since they basically just teleport).Įdit: also, from other reviews, there seems to be lots of ads, well, just use an ad-blocker lol. Another suggestion is that you remove the option to like go off the slide, reason being is that I can just go off the slide and be at the end in seconds (which doesn’t make it very entertaining). If the game added actual players to play with you then it’ll definitely be more competitive and fun since what’s the point if their all bots and catch up with you within a blink of an eye. This is one of the main reasons why I believe all these “other people/players” are bots and the game intended to be like this. Next, I’ve figured out that no matter how far you are than other “people” they will catch up within like 1-2 seconds (like you could be wayyyy at the end but if their at the start they can come in like 1-2 seconds). Also, I always start in the 16th position which is probably intentional (so it isn’t really fair). Why? Because like most other “competition mobile games” the “other players” are bots. At first, this game was pretty entertaining and fun to play. 10/6/2023 0 Comments Game like melvor idle
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